When most people think of menopause, the first symptoms that come to mind are often hot flashes and night sweats. While these are certainly some of the most common and uncomfortable aspects of menopause, they represent just a fraction of the challenges women face during this significant life transition. Menopause is a multifaceted experience, affecting everything from mood and sleep to joint health and sexual function. For women seeking comprehensive support during this time, rhapontic rhubarb root extract emerges as a powerful option, offering relief far beyond the typical symptoms.
The Menopause Rating Scale: A Comprehensive View of Menopausal Symptoms
The Menopause Rating Scale (MRS) is a widely used tool that measures the severity of a range of menopausal symptoms. It encompasses 11 symptoms across three domains: psychological, somatic and urogenital.1
Psychological: Depressive mood, irritability, anxiety and mental exhaustion
Somatic: Hot flashes, night sweats, heart discomfort, sleep problems and muscle/joint pain
Urogenital: Sexual problems, bladder issues and vaginal dryness
Understanding how a treatment impacts these varied symptoms is crucial for providing comprehensive and effective menopause support.
Introducing Rhapontic Rhubarb Root Extract: A Natural Solution
Rhapontic rhubarb (Rheum rhaponticum) has been used traditionally in European herbal medicine for centuries. The extract from its root is rich in phytoestrogens—plant-based compounds that mimic the effects of estrogen in the body. This is particularly beneficial during menopause when a woman’s natural estrogen levels begin to decline.
Unlike synthetic hormone replacement therapies (HRT), rhapontic rhubarb root extract offers a more natural approach, modulating estrogenic activity without the associated risks of HRT.2,3 But what makes this extract truly remarkable is its comprehensive mechanism of action, targeting the wide array of symptoms experienced during menopause.
Mechanisms of Action: Addressing the Full Spectrum of Menopausal Symptoms
Estrogenic Activity and Hormonal Balance
Rhapontic rhubarb root extract contains compounds like rhaponticin and desoxy-rhaponticin that bind to estrogen receptors in the body. These phytoestrogens primarily interact with estrogen receptor-beta (ER-β), which is associated with the regulation of the nervous system, bone health and cardiovascular function. This contrasts with other phytoestrogens that also bind estrogen receptor-alpha (ER-α), which is associated with increased proliferation. By modulating estrogenic activity, this extract helps alleviate symptoms such as hot flashes, night sweats and vaginal dryness, which are directly linked to a decline in estrogen levels. 4,5,6,7
Mood and Cognitive Support
Menopausal women often experience mood swings, irritability and even depression, driven in part by hormonal fluctuations. Rhapontic rhubarb root extract supports mental wellbeing by balancing estrogen levels and interacting with neurotransmitters that regulate mood, such as serotonin and dopamine. This helps to ease psychological symptoms like depressive mood, anxiety and mental exhaustion.8,9
Sleep Enhancement
Sleep disturbances are another common issue during menopause, often exacerbated by night sweats and hormonal imbalances. The extract’s ability to stabilize hormone levels, particularly by reducing the frequency and severity of hot flashes, contributes to better sleep quality. Additionally, its calming effects on the nervous system further support restful sleep. 10,11
Urogenital Support
Vaginal dryness, bladder issues and sexual problems can severely impact a woman’s quality of life during menopause. Rhapontic rhubarb root extract improves urogenital health by increasing moisture in the vaginal tissues and supporting overall urinary tract function. This not only enhances comfort but also contributes to a healthier sexual life and reduced urinary symptoms. 10,11
Cardiovascular and Musculoskeletal Health
Heart discomfort and joint pain are somatic symptoms often overlooked in menopause management. The phytoestrogens in rhapontic rhubarb root extract play a role in maintaining cardiovascular health by supporting blood vessel function and reducing inflammation, which can help alleviate heart discomfort. Additionally, by promoting bone health and reducing inflammation in joints, the extract helps mitigate muscle and joint pain, which is crucial for maintaining mobility and quality of life during menopause. 10,11,12
The Bottom Line
Menopause is a complex transition that affects each woman differently, making it essential to find a solution that offers comprehensive support. Rhapontic rhubarb root extract stands out as a natural solution that addresses the full spectrum of menopausal symptoms, as measured by the Menopause Rating Scale.
By targeting the underlying hormonal imbalances and providing support across psychological, somatic and urogenital domains, this extract ensures that women can navigate menopause with greater confidence and ease—far beyond just relief from hot flashes and night sweats.
Incorporating rhapontic rhubarb root extract into a daily regimen can help women feel their best during this life stage, empowering them to embrace the next chapter with vitality and grace.
Joanna Matras-Godziejewicz, ND, PhD is a licensed practitioner dedicated to holistic medicine. Inspired by psychosomatic medicine and the intricacies of the human brain, she earned her PhD in Neuroscience from Rush University Medical College in 2013, specializing in neurodegenerative disorders. Driven by a passion for the inter-relationship of the body's organs and systems, Joanna discovered Naturopathic Medicine. A graduate of the National University of Health Sciences in Lombard, Illinois, she holds a Naturopathic Doctorate. With a focus on neurology and endocrinology, Joanna has been in private practice since 2020, empowering patients to understand their bodies and embrace the power of functional medicine. Her clinical expertise in treating hormone-related issues has led to her current role as the Clinical Brand Manager for the Hormone Health and SOS lines
References
- Schneider, H. P. G., & Heinemann, L. A. J. (2003). The menopause rating scale (MRS) as outcome measure for hormone treatment? A methodological comparison between the MRS and the Kupperman index. Health and Quality of Life Outcomes, 1(1), 1-9.
- Shulman, L. P. (2010). The pros and cons of hormone replacement therapy. The Female Patient, 35(3), 33-38.
- Hasper I, Ventskovskiy BM, Rettenberger R, et al. Longterm efficacy and safety of the special extract ERr 731 of Rheum rhaponticum in perimenopausal women with menopausal symptoms. Menopause. 2009;16(1):117-131.
- Pϋssa T, Raudsepp P, Kuzina K, Raal A. Polyphenolic composition of roots and perioles of Rheum rhaponticum L. Phytochem Anal. 2009;20(2):98-103.
- Vollmer G, Papke A, Zierau O. Treatment of menopausal symptoms by an extract from the roots of rhapontic rhubarb: the role of estrogen receptors. Chin Med. 2010;5:7.
- Riley DS, Vollmer G, Kaskin-Bettag M. Mechanisms of action of the Rheum rhaponticum (Siberian rhubarb) special extract ERr 731®. Presented at the 8th Meeting of the North American Menopause Society, October 3-6, 2007, Dallas, TX abstract no. 8.
- Palacios, S., Mejía, A., & Neyro, J. L. (2009). Selective estrogen receptor modulators. Clinical Interventions in Aging, 4, 291.
- Kaszkin-Bettag M, Ventskovsky BM, Kravchenko A, et al. The special extract ERr 731 of the roots of Rheum rhaponticum decreases anxiety and improves health state and general well-being in perimenopausal women. Menopause. 2007;14(2):270-283.
- Kaszkin-Bettag M. Letters to the editor. Menopause. 2007;14(2):331-338.
- Heger M, Ventskovskiy BM, Borzenko I, Kneis KC, Rettenberger R, Kaskzkin-Bettag M, Heger PW. Efficacy and safety of a special extract of Rheum rhaponticum (ERr 731) in perimenopausal women with climacteric complaints: a 12-week randomized, double-blind, placebo-controlled trial. Menopause. 2006;13(5):744-759.
- Kaszkin-Bettag M, Beck S, Richardson A, Heger PW, Beer AM. Efficacy of the special extract ERr 731 from rhapontic rhubarb for menopausal complaints: a 6-month open observational study. Altern Ther Health Med. 2008;14(6):32-38.
- Lejsková, M., Alusik, S., Valis, M., & Lampartová, I. (2010). Phytoestrogens and the metabolic syndrome. Climacteric, 13(1), 68-78.